In Lucky Them, we follow the journey of Ellie Klug (Toni Collette), a struggling journalist in her 40s who isn't finding much luck in dating nor her career. When most of her contemporaries have settled into stable lives, Ellie still falls into the same pattern of hooking up with musicians she is writing about. Perhaps what's at core of this fixation stems from her failed relationship with famous musician, Matthew Smith (Johnny Depp), who disappeared mysteriously 10 years ago. Some speculated that Matthew committed suicide, however no one really knows the real story, including Ellie.
In order to save her career, she has to write a feature on Matthew, a painful assignment given by her magazine's editor (Oliver Platt). Ellie then embarks on an emotional hunt of exploring her own past with wealthy socialite, Charlie (Thomas Haden Church), who agrees to lend her money in exchange for documenting her journey. Will she find Matthew and finally rid herself of her "ghosts"?